List of publications

2022

Mitochondrial Function and Microbial Metabolites as Central Regulators of Intestinal Immune Responses and Cancer. Weber-Stiehl S, Järke L, Castrillón-Betancur JC, Gilbert F, Sommer F. Front Microbiol. 2022 Jun 29;13:919424. doi: 10.3389/fmicb.2022.919424. eCollection 2022. PMID: 35847099

Single-cell atlas of the aging mouse colon. Širvinskas D, Omrani O, Lu J, Rasa M, Krepelova A, Adam L, Kaeppel S, Sommer F, Neri F. iScience. 2022 Apr 4;25(5):104202. doi: 10.1016/j.isci.2022.104202. eCollection 2022 May 20. PMID: 35479413

Staying strong during hibernation. Sommer F, Bäckhed F. Science. 2022 Jan 28;375(6579):376-377. doi: 10.1126/science.abn6187. Epub 2022 Jan 27. PMID: 35084958

PUFA-induced metabolic enteritis as a fuel for Crohn’s disease. Schwärzler J, Mayr L, Vila AV, Grabherr F, Niederreiter L, Philipp M, Grander C, Meyer M, Jukic A, Tröger S, Enrich B, Przysiecki N, Tschurtschenthaler M, Sommer F, Kronberger I, Koch J, Hilbe R, Hess MW, Oberhuber G, Sprung S, Ran Q, Koch R, Effenberger M, Kaneider NC, Wieser V, Keller MA, Weersma RK, Aden K, Rosenstiel P, Blumberg RS, Kaser A, Tilg H, Adolph TE. Gastroenterology. 2022 Jan 11:S0016-5085(22)00012-9. doi: 10.1053/j.gastro.2022.01.004. PMID: 35031299

2021

Microbial regulation of hexokinase 2 links mitochondrial metabolism and cell death in colitis. Hinrichsen F, Hamm J, Westermann M, Schröder L, Shima K, Mishra N, Walker A, Sommer N, Klischies K, Prasse D, Zimmermann J, Kaiser S, Bordoni D, Fazio A, Marinos G, Laue G, Imm S, Tremaroli V, Basic M, Häsler R, Schmitz RA, Krautwald S, Wolf A, Stecher B, Schmitt-Kopplin P, Kaleta C, Rupp J, Bäckhed F, Rosenstiel P, Sommer F. Cell Metab. 2021 Dec 7;33(12):2355-2366.e8. doi: 10.1016/j.cmet.2021.11.004. Epub 2021 Nov 29. PMID: 34847376

The gut microbiota instructs the hepatic endothelial cell transcriptome. Formes H, Bernardes JP, Mann A, Bayer F, Pontarollo G, Kiouptsi K, Schäfer K, Attig S, Nikolova T, Hofmann TG, Schattenberg JM, Todorov H, Gerber S, Rosenstiel P, Bopp T, Sommer F, Reinhardt C. iScience. 2021 Sep 10;24(10):103092. doi: 10.1016/j.isci.2021.103092. eCollection 2021 Oct 22. PMID: 34622147

Short-term physical exercise impacts on the human holobiont obtained by a randomised intervention study. Moitinho-Silva L, Wegener M, May S, Schrinner F, Akhtar A, Boysen TJ, Schaeffer E, Hansen C, Schmidt T, Rühlemann MC, Hübenthal M, Rausch P, Kondakci MT, Maetzler W, Weidinger S, Laudes M, Süß P, Schulte D, Junker R, Sommer F, Weisser B, Bang C, Franke A. BMC Microbiol. 2021 Jun 2;21(1):162. doi: 10.1186/s12866-021-02214-1. PMID: 34078289

2020

Precision Nutrition in Chronic Inflammation. Demetrowitsch TJ, Schlicht K, Knappe C, Zimmermann J, Jensen-Kroll J, Pisarevskaja A, Brix F, Brandes J, Geisler C, Marinos G, Sommer F, Schulte DM, Kaleta C, Andersen V, Laudes M, Schwarz K, Waschina S. Front Immunol. 2020 Nov 23;11:587895. doi: 10.3389/fimmu.2020.587895. eCollection 2020. PMID: 33329569

Nutritional Targeting of the Microbiome as Potential Therapy for Malnutrition and Chronic Inflammation. Schröder L & Kaiser S, Flemer B, Hamm J, Hinrichsen F, Bordoni D, Rosenstiel P, Sommer F. Nutrients. 2020 Oct 3;12(10):E3032. doi: 10.3390/nu12103032. PMID: 33022941

A high-fat diet induces a microbiota-dependent increase in stem cell activity in the Drosophila intestine. von Frieling J, Faisal MN, Sporn F, Pfefferkorn R, Nolte SS, Sommer F, Rosenstiel P, Roeder T. PLoS Genet. 2020 May 26;16(5):e1008789. doi: 10.1371/journal.pgen.1008789. eCollection 2020 May. PMID: 32453733

NOD2 influences trajectories of intestinal microbiota recovery after antibiotic perturbation. Anderson JM*, Lipinski S*, Sommer F*, Pan WH, Boulard O, Rehman A, Falk-Paulsen M, Stengel ST, Aden K, Häsler R, Bharti R, Künzel S, Baines JF, Chamaillard M, Rosenstiel P. Cell Mol Gastroenterol Hepatol. 2020 Apr 11. pii: S2352-345X(20)30044-8. doi: 10.1016/j.jcmgh.2020.03.008. [Epub ahead of print] PMID: 32289499
*shared first-authorship

Dietary lipids fuel GPX4-restricted enteritis resembling Crohn’s disease. Mayr L, Grabherr F, Schwärzler J, Reitmeier I, Sommer F, Gehmacher T, Niederreiter L, He GW, Ruder B, Kunz KTR, Tymoszuk P, Hilbe R, Haschka D, Feistritzer C, Gerner RR, Enrich B, Przysiecki N, Seifert M, Keller MA, Oberhuber G, Sprung S, Ran Q, Koch R, Effenberger M, Tancevski I, Zoller H, Moschen AR, Weiss G, Becker C, Rosenstiel P, Kaser A, Tilg H, Adolph TE. Nat Commun. 2020 Apr 14;11(1):1775. doi: 10.1038/s41467-020-15646-6. PMID: 32286299

α-Linolenic Acid-Rich Diet Influences Microbiota Composition and Villus Morphology of the Mouse Small Intestine. Todorov H, Kollar B, Bayer F, Brandão I, Mann A, Mohr J, Pontarollo G, Formes H, Stauber R, Kittner JM, Endres K, Watzer B, Nockher WA, Sommer F, Gerber S, Reinhardt C. Nutrients. 2020 Mar 11;12(3). pii: E732. doi: 10.3390/nu12030732. PMID: 32168729

2019

Advancing Our Functional Understanding of Host-Microbiota Interactions: A Need for New Types of Studies. He J, Lange J, Marinos G, Bathia J, Harris D, Soluch R, Vaibhvi V, Deines P, Hassani MA, Wagner KS, Zapien-Campos R, Jaspers C, Sommer F. Bioessays. 2019 Dec 18:e1900211. doi: 10.1002/bies.201900211. [Epub ahead of print] PubMed PMID: 31854014.

The Microbiota Promotes Arterial Thrombosis in Low-Density Lipoprotein Receptor-Deficient Mice. Kiouptsi K, Jäckel S, Pontarollo G, Grill A, Kuijpers MJE, Wilms E, Weber C, Sommer F, Nagy M, Neideck C, Jansen Y, Ascher S, Formes H, Karwot C, Bayer F, Kollar B, Subramaniam S, Molitor M, Wenzel P, Rosenstiel P, Todorov H, Gerber S, Walter U, Jurk K, Heemskerk JWM, van der Vorst EPC, Döring Y, Reinhardt C. mBio. 2019 Oct 22;10(5). pii: e02298-19. doi: 10.1128/mBio.02298-19. PubMed PMID: 31641089; PubMed Central PMCID: PMC6805995.

Comparative analysis of amplicon and metagenomic sequencing methods reveals key features in the evolution of animal metaorganisms.Rausch P, Rühlemann M, Hermes BM, Doms S, Dagan T, Dierking K, Domin H, Fraune S, von Frieling J, Hentschel U, Heinsen FA, Höppner M, Jahn MT, Jaspers C, Kissoyan KAB, Langfeldt D, Rehman A, Reusch TBH, Roeder T, Schmitz RA, Schulenburg H, Soluch R, Sommer F, Stukenbrock E, Weiland-Bräuer N, Rosenstiel P, Franke A, Bosch T, Baines JF. Microbiome. 2019 Sep 14;7(1):133. doi: 10.1186/s40168-019-0743-1. PubMed PMID: 31521200; PubMed Central PMCID: PMC6744666.

Functions of the Microbiota for the Physiology of Animal Metaorganisms. Esser D, Lange J, Marinos G, Sieber M, Best L, Prasse D, Bathia J, Rühlemann MC, Boersch K, Jaspers C, Sommer F. J Innate Immun. 2019;11(5):393-404. doi: 10.1159/000495115. Epub 2018 Dec 19. Review. PubMed PMID: 30566939; PubMed Central PMCID: PMC6738199.

2018

Grow With the Challenge – Microbial Effects on Epithelial Proliferation, Carcinogenesis, and Cancer Therapy. von Frieling J, Fink C, Hamm J, Klischies K, Forster M, Bosch TCG, Roeder T, Rosenstiel P, Sommer F. Front Microbiol. 2018 Sep 20;9:2020. doi: 10.3389/fmicb.2018.02020. eCollection 2018. Review. PubMed PMID: 30294304; PubMed Central PMCID: PMC6159313.

Neonatal selection by Toll-like receptor 5 influences long-term gut microbiota composition. Fulde M, Sommer F, Chassaing B, van Vorst K, Dupont A, Hensel M, Basic M, Klopfleisch R, Rosenstiel P, Bleich A, Bäckhed F, Gewirtz AT, Hornef MW. Nature. 2018 Aug;560(7719):489-493. doi: 10.1038/s41586-018-0395-5. Epub 2018 Aug 8. Erratum in: Nature. 2018 Nov;563(7731):E25. PubMed PMID: 30089902.

Exposure to the gut microbiota drives distinct methylome and transcriptome changes in intestinal epithelial cells during postnatal development. Pan WH, Sommer F, Falk-Paulsen M, Ulas T, Best P, Fazio A, Kachroo P, Luzius A, Jentzsch M, Rehman A, Müller F, Lengauer T, Walter J, Künzel S, Baines JF, Schreiber S, Franke A, Schultze JL, Bäckhed F, Rosenstiel P. Genome Med. 2018 Apr 13;10(1):27. doi: 10.1186/s13073-018-0534-5. PubMed PMID: 29653584; PubMed Central PMCID: PMC5899322.
*shared first-authorship

2017

Microbiomarkers in inflammatory bowel diseases: caveats come with caviar. Sommer F, Rühlemann MC, Bang C, Höppner M, Rehman A, Kaleta C, Schmitt-Kopplin P, Dempfle A, Weidinger S, Ellinghaus E, Krauss-Etschmann S, Schmidt-Arras D, Aden K, Schulte D, Ellinghaus D, Schreiber S, Tholey A, Rupp J, Laudes M, Baines JF, Rosenstiel P, Franke A. Gut. 2017 Oct;66(10):1734-1738. doi: 10.1136/gutjnl-2016-313678. Epub 2017 Jul 21. PubMed PMID: 28733278; PubMed Central PMCID: PMC5595102.

The resilience of the intestinal microbiota influences health and disease. Sommer F, Anderson JM, Bharti R, Raes J, Rosenstiel P. Nat Rev Microbiol. 2017 Oct;15(10):630-638. doi: 10.1038/nrmicro.2017.58. Epub 2017 Jun 19. Review. PubMed PMID: 28626231.

2016

Genome-wide association analysis identifies variation in vitamin D receptor and other host factors influencing the gut microbiota. Wang J, Thingholm LB, Skiecevičienė J, Rausch P, Kummen M, Hov JR, Degenhardt F, Heinsen FA, Rühlemann MC, Szymczak S, Holm K, Esko T, Sun J, Pricop-Jeckstadt M, Al-Dury S, Bohov P, Bethune J, Sommer F, Ellinghaus D, Berge RK, Hübenthal M, Koch M, Schwarz K, Rimbach G, Hübbe P, Pan WH, Sheibani-Tezerji R, Häsler R, Rosenstiel P, D’Amato M, Cloppenborg-Schmidt K, Künzel S, Laudes M, Marschall HU, Lieb W, Nöthlings U, Karlsen TH, Baines JF, Franke A. Nat Genet. 2016 Nov;48(11):1396-1406. doi: 10.1038/ng.3695. Epub 2016 Oct 10. PubMed PMID: 27723756; PubMed Central PMCID: PMC5626933.

Age-Dependent Susceptibility to Enteropathogenic Escherichia coli (EPEC) Infection in Mice. Dupont A, Sommer F, Zhang K, Repnik U, Basic M, Bleich A, Kühnel M, Bäckhed F, Litvak Y, Fulde M, Rosenshine I, Hornef MW. PLoS Pathog. 2016 May 9;12(5):e1005616. doi: 10.1371/journal.ppat.1005616. eCollection 2016 May. PubMed PMID: 27159323; PubMed Central PMCID: PMC4861285.

Know your neighbor: Microbiota and host epithelial cells interact locally to control intestinal function and physiology. Sommer F, Bäckhed F. Bioessays. 2016 May;38(5):455-64. doi: 10.1002/bies.201500151. Epub 2016 Mar 18. Review. PubMed PMID: 26990415.

The Gut Microbiota Modulates Energy Metabolism in the Hibernating Brown Bear Ursus arctos. Sommer F, Ståhlman M, Ilkayeva O, Arnemo JM, Kindberg J, Josefsson J, Newgard CB, Fröbert O, Bäckhed F. Cell Rep. 2016 Feb 23;14(7):1655-1661. doi: 10.1016/j.celrep.2016.01.026. Epub 2016 Feb 4. PubMed PMID: 26854221.

Microbiota-induced obesity requires farnesoid X receptor. Parséus A, Sommer N, Sommer F, Caesar R, Molinaro A, Ståhlman M, Greiner TU, Perkins R, Bäckhed F. Gut. 2017 Mar;66(3):429-437. doi: 10.1136/gutjnl-2015-310283. Epub 2016 Jan 6. PubMed PMID: 26740296; PubMed Central PMCID: PMC5534765.

2015

Neurotensin Is Coexpressed, Coreleased, and Acts Together With GLP-1 and PYY in Enteroendocrine Control of Metabolism. Grunddal KV, Ratner CF, Svendsen B, Sommer F, Engelstoft MS, Madsen AN, Pedersen J, Nøhr MK, Egerod KL, Nawrocki AR, Kowalski T, Howard AD, Poulsen SS, Offermanns S, Bäckhed F, Holst JJ, Holst B, Schwartz TW. Endocrinology. 2016 Jan;157(1):176-94. doi: 10.1210/en.2015-1600. Epub 2015 Oct 15. PubMed PMID: 26469136.

Site-specific programming of the host epithelial transcriptome by the gut microbiota. Sommer F, Nookaew I, Sommer N, Fogelstrand P, Bäckhed F. Genome Biol. 2015 Mar 28;16:62. doi: 10.1186/s13059-015-0614-4. PubMed PMID: 25887251; PubMed Central PMCID: PMC4404278.

2014

The composition of the gut microbiota shapes the colon mucus barrier. Jakobsson HE, Rodríguez-Piñeiro AM, Schütte A, Ermund A, Boysen P, Bemark M, Sommer F, Bäckhed F, Hansson GC, Johansson ME. EMBO Rep. 2015 Feb;16(2):164-77. doi: 10.15252/embr.201439263. Epub 2014 Dec 18. PubMed PMID: 25525071; PubMed Central PMCID: PMC4328744.

Regulation of polyp-to-jellyfish transition in Aurelia aurita. Fuchs B, Wang W, Graspeuntner S, Li Y, Insua S, Herbst EM, Dirksen P, Böhm AM, Hemmrich G, Sommer F, Domazet-Lošo T, Klostermeier UC, Anton-Erxleben F, Rosenstiel P, Bosch TC, Khalturin K. Curr Biol. 2014 Feb 3;24(3):263-73. doi: 10.1016/j.cub.2013.12.003. Epub 2014 Jan 16. PubMed PMID: 24440392.

Altered mucus glycosylation in core 1 O-glycan-deficient mice affects microbiota composition and intestinal architecture. Sommer F, Adam N, Johansson ME, Xia L, Hansson GC, Bäckhed F. PLoS One. 2014 Jan 9;9(1):e85254. doi: 10.1371/journal.pone.0085254. eCollection 2014. PubMed PMID: 24416370; PubMed Central PMCID: PMC3887012.

2013

The gut microbiota–masters of host development and physiology. Sommer F, Bäckhed F. Nat Rev Microbiol. 2013 Apr;11(4):227-38. doi: 10.1038/nrmicro2974. Epub 2013 Feb 25. Review. PubMed PMID: 23435359.

2012

Blood system formation in the urochordate Ciona intestinalis requires the variable receptor vCRL1. Sommer F, Awazu S, Anton-Erxleben F, Jiang D, Klimovich AV, Klimovich BV, Samoilovich MP, Satou Y, Krüss M, Gelhaus C, Kürn U, Bosch TC, Khalturin K. Mol Biol Evol. 2012 Oct;29(10):3081-93. Epub 2012 Apr 18. PubMed PMID: 22513285.

2007

In the urochordate Ciona intestinalis zona pellucida domain proteins vary among individuals. Kürn U, Sommer F*, Bosch TC, Khalturin K. Dev Comp Immunol. 2007;31(12):1242-54. Epub 2007 Apr 26. PubMed PMID: 17499356.
*shared first-authorship

Allorecognition in urochordates: identification of a highly variable complement receptor-like protein expressed in follicle cells of Ciona. Kürn U, Sommer F, Hemmrich G, Bosch TC, Khalturin K. Dev Comp Immunol. 2007;31(4):360-71. Epub 2006 Aug 8. PubMed PMID: 17074389.